The cellular target of histatin 5 on Candida albicans is the energized mitochondrion.

@article{Helmerhorst1999TheCT,
  title={The cellular target of histatin 5 on Candida albicans is the energized mitochondrion.},
  author={E J Helmerhorst and Pieter Breeuwer and Wouter van't Hof and Els Walgreen-Weterings and Lauran C. J. M. Oomen and Enno C. I. Veerman and Arie V Van Nieuw Amerongen and Tjakko Abee},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 11},
  pages={7286-91}
}
Histatin 5 is a human basic salivary peptide with strong fungicidal properties in vitro. To elucidate the mechanism of action, the effect of histatin 5 on the viability of Candida albicans cells was studied in relation to its membrane perturbing properties. It was found that both the killing activity and the membrane perturbing activity, studied by the influx of a DNA-specific marker propidium iodide, were inhibited by high salt conditions and by metabolic inhibitors, like sodium azide. In… CONTINUE READING
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