The cellular response to unfolded proteins: intercompartmental signaling.

  title={The cellular response to unfolded proteins: intercompartmental signaling.},
  author={Daniel McMillan and M J Gething and Joe Sambrook},
  journal={Current opinion in biotechnology},
  volume={5 5},
Both prokaryotic and eukaryotic cells respond to the accumulation of unfolded proteins by increasing the transcription of genes encoding molecular chaperones and other stress-responsive proteins. Different sets of genes are activated when particular cellular compartments are burdened with unfolded proteins. Cells thus maintain mechanisms to monitor changes in the concentration of unfolded proteins not only in the cytosol, but also in membrane-bound extracytoplasmic compartments. During the past… CONTINUE READING

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