The cellular prion protein colocalizes with the dystroglycan complex in the brain.

@article{Keshet2000TheCP,
  title={The cellular prion protein colocalizes with the dystroglycan complex in the brain.},
  author={Gilmor I. Keshet and O Bar-Peled and David Yaffe and Uri Nudel and Ruth Gabizon},
  journal={Journal of neurochemistry},
  year={2000},
  volume={75 5},
  pages={1889-97}
}
The function of PrP(C), the cellular prion protein (PrP), is still unknown. Like other glycophosphatidylinositol-anchored proteins, PrP resides on Triton-insoluble, cholesterol-rich membranous microdomains, termed rafts. We have recently shown that the activity and subcellular localization of the neuronal isoform of nitric oxide synthase (nNOS) are impaired in adult PrP(0/0) mice as well as in scrapie-infected mice. In this study, we sought to determine whether PrP and nNOS are part of the same… CONTINUE READING