The cellular neurobiology of depression

@article{Manji2001TheCN,
  title={The cellular neurobiology of depression},
  author={Husseini K. Manji and Wayne C. Drevets and Dennis S. Charney},
  journal={Nature Medicine},
  year={2001},
  volume={7},
  pages={541-547}
}
Major depressive disorders, long considered to be of neurochemical origin, have recently been associated with impairments in signaling pathways that regulate neuroplasticity and cell survival. Agents designed to directly target molecules in these pathways may hold promise as new therapeutics for depression. 
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