The cellular mechanism for water detection in the mammalian taste system

@article{Zocchi2017TheCM,
  title={The cellular mechanism for water detection in the mammalian taste system},
  author={Dhruv Zocchi and Gunther Wennemuth and Yuki Oka},
  journal={Nature Neuroscience},
  year={2017},
  volume={20},
  pages={927-933}
}
Initiation of drinking behavior relies on both internal state and peripheral water detection. While central neural circuits regulating thirst have been well studied, it is still unclear how mammals recognize external water. Here we show that acid-sensing taste receptor cells (TRCs) that were previously suggested as the sour taste sensors also mediate taste responses to water. Genetic silencing of these TRCs abolished water-evoked responses in taste nerves. Optogenetic self-stimulation of acid… CONTINUE READING
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