The cellular mechanism by which complementary Id+ and anti-Id antibodies communicate: T cells integrated into idiotypic regulation.

@article{Jacobsen2010TheCM,
  title={The cellular mechanism by which complementary Id+ and anti-Id antibodies communicate: T cells integrated into idiotypic regulation.},
  author={Johanne Tracey Jacobsen and Elin Lunde and Vibeke Sundvold-Gjerstad and Ludvig Andr{\'e} Munthe and Bjarne Bogen},
  journal={Immunology and cell biology},
  year={2010},
  volume={88 5},
  pages={
          515-22
        }
}
The V region antigenic determinants (idiotopes (Ids)) of antibodies (Abs) have been suggested to be involved in regulating the immune system. Certain diseases such as diabetes mellitus have recently been associated with a disequilibrium between Id(+) and anti-Id Abs. However, it is unknown how Abs carrying complementary idiotypes (that is, Id(+) and anti-Id Abs) regulate each other at the level of B and T cells. In this study, we show that B lymphoma cells genetically equipped with anti-Id BCR… CONTINUE READING

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