The cellular fate of glucose and its relevance in type 2 diabetes.

  title={The cellular fate of glucose and its relevance in type 2 diabetes.},
  author={Clara Bouch{\'e} and Shanti Serdy and C Ronald Kahn and Allison B. Goldfine},
  journal={Endocrine reviews},
  volume={25 5},
Type 2 diabetes is a complex disorder with diminished insulin secretion and insulin action contributing to the hyperglycemia and wide range of metabolic defects that underlie the disease. The contribution of glucose metabolic pathways per se in the pathogenesis of the disease remains unclear. The cellular fate of glucose begins with glucose transport and phosphorylation. Subsequent pathways of glucose utilization include aerobic and anaerobic glycolysis, glycogen formation, and conversion to… CONTINUE READING
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