The cellular basis for immune interferon production in autoimmune MRL-Ipr/Ipr mice.

@article{Santoro1983TheCB,
  title={The cellular basis for immune interferon production in autoimmune MRL-Ipr/Ipr mice.},
  author={Thomas Santoro and Weiss Benjamin and Joost J Oppenheim and Alfred D. Steinberg},
  journal={Journal of immunology},
  year={1983},
  volume={131 1},
  pages={265-8}
}
Disturbances in immune interferon (IFN gamma) activity have been implicated in the development of human systemic lupus erythematosus (SLE) and the spontaneous disease sustained by autoimmune-prone mice. We therefore investigated the cellular basis for IFN gamma production in MRL-Ipr/Ipr mice and examined the relationship between synthesis of interleukin 2 (IL 2) and IFN gamma. In vitro IL 2 and IFN gamma production in 3 to 6-mo-old, autoimmune MRL-Ipr/Ipr and MRL-+/+ mice was compared with that… CONTINUE READING

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