The cellular and molecular pathogenesis of colorectal cancer.

  title={The cellular and molecular pathogenesis of colorectal cancer.},
  author={John M. Carethers},
  journal={Gastroenterology clinics of North America},
  volume={25 4},
The development of colorectal neoplasia originates from normal colonic mucosa, progresses to the adenomatous polyp, and later may evolve into carcinoma. This procession of histologic change can be defined by a series of successive waves of clonal expansion that contain certain genetic alterations. These genetic alterations include mutations in the K-ras oncogene and mutation in the one allele coupled with loss of the second allele for the tumor suppressor genes APC, DCC, and p53. The normal… CONTINUE READING