The cellular and clinical parameters of anabolic therapy for osteoporosis.

@article{Rosen2003TheCA,
  title={The cellular and clinical parameters of anabolic therapy for osteoporosis.},
  author={Clifford J. Rosen},
  journal={Critical reviews in eukaryotic gene expression},
  year={2003},
  volume={13 1},
  pages={25-38}
}
A new era in the management of osteoporosis began with the recent approval of parathyroid hormone (PTH) for the treatment of postmenopausal osteoporosis. This peptide holds promise as the first in a series of anabolic growth factors that promote bone formation, enhance mineralization,and stimulate periosteal growth, yet exert relatively limited effects on bone resorption. Daily intermittent PTH treatment for postmenopausal women results in a dramatic increase in bone mineral density (BMD) (i.e… CONTINUE READING