The cell wall mediates pneumococcal attachment to and cytopathology in human endothelial cells.

@article{Geelen1993TheCW,
  title={The cell wall mediates pneumococcal attachment to and cytopathology in human endothelial cells.},
  author={Sibyl P. M. Geelen and Chiranjib Bhattacharyya and Elaine I Tuomanen},
  journal={Infection and immunity},
  year={1993},
  volume={61 4},
  pages={1538-43}
}
Streptococcus pneumoniae interacts with vascular endothelial cells during the course of bacteremia. In this study, we characterized the initial attachment of pneumococci to human endothelial cells (EC) and the response of the endothelium to this interaction. Pneumococci adhered to EC in a dose-dependent fashion. Attachment was rapid, with the majority of bacteria attached by 30 min. No difference was found between the attachment of unencapsulated (R6) and encapsulated (SIII) strains. Purified… CONTINUE READING