The cell-layer- and cell-type-specific distribution of GalNAc-transferases in the ocular surface epithelia is altered during keratinization.

@article{Argeso2003TheCA,
  title={The cell-layer- and cell-type-specific distribution of GalNAc-transferases in the ocular surface epithelia is altered during keratinization.},
  author={Pablo Arg{\"u}eso and Ann S. Tisdale and Ulla Mandel and Erik Letko and Charles Stephen Foster and Ilene K. Gipson},
  journal={Investigative ophthalmology & visual science},
  year={2003},
  volume={44 1},
  pages={86-92}
}
PURPOSE It has been hypothesized that the biosynthesis of O-linked glycans on proteins, particularly on the highly O-glycosylated mucins, by the corneal and conjunctival epithelium is necessary for the protection and maintenance of a healthy ocular surface. The initial step in O-glycosylation is the enzymatic addition of N-acetyl galactosamine (GalNAc) to serine and threonine residues by a large family of polypeptide GalNAc-transferases (GalNAc-Ts). The purpose of this study was to determine… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 30 references

Cicatricial pemphigoid

CS Foster
Trans Am Ophthalmol Soc • 1986
View 9 Excerpts
Highly Influenced

Cloning and characterization of a ninth member of the UDP-GalNAc:polypeptide Nacetylgalactosaminyltransferase family, ppGaNTase-T9

KG Ten Hagen, GS Bedi, D Tetaert
J Biol Chem • 2001

Control of mucin-type O-glycosylation: O-glycan occupancy is directed by substrate specificities of polypeptide GalNAc-transferases

H Hassan, EP Bennett, U Mandel, MA Hollingsworth, H. Clausen
Oligosaccharides in Chemistry and Biology: A Comprehensive Handbook. Weinheim, • 2000

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