The cell junction protein VAB-9 regulates adhesion and epidermal morphology in C. elegans

  title={The cell junction protein VAB-9 regulates adhesion and epidermal morphology in C. elegans},
  author={Jeffrey S. Simske and Mathias Koeppen and Paul Francis George Sims and Jonathan Hodgkin and Alicia L Yonkof and Jeff Hardin},
  journal={Nature Cell Biology},
Epithelial cell junctions are essential for cell polarity, adhesion and morphogenesis. We have analysed VAB-9, a cell junction protein in Caenorhabditis elegans. VAB-9 is a predicted four-pass integral membrane protein that has greatest similarity to BCMP1 (brain cell membrane protein 1, a member of the PMP22/EMP/Claudin family of cell junction proteins) and localizes to the adherens junction domain of C. elegans apical junctions. Here, we show that VAB-9 requires HMR-1/cadherin for… CONTINUE READING


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