The cell death-inducing activity of the peptide containing Noxa mitochondrial-targeting domain is associated with calcium release.

  title={The cell death-inducing activity of the peptide containing Noxa mitochondrial-targeting domain is associated with calcium release.},
  author={Young Woo Seo and Ha Na Woo and Sujan Piya and Ae Ran Moon and Jae-Wook Oh and Cheol-Won Yun and Kyung-Keun Kim and Ji-young Min and Seon‐Yong Jeong and Seyung S Chung and Peter I. Song and Seong-Yun Jeong and Eun Kyung Choi and Dai-wu Seol and Tae-Hyoung Kim},
  journal={Cancer research},
  volume={69 21},
DNA damage stabilizes the p53 tumor suppressor protein that determines the cell fate by either cell cycle arrest or cell death induction. Noxa, the BH3-only Bcl-2 family protein, was shown to be a key player in p53-induced cell death through the mitochondrial dysfunction; however, the molecular mechanism by which Noxa induces the mitochondrial dysfunction to cause cell death in response to genotoxic agents is largely unknown. Here, we show that the mitochondrial-targeting domain (MTD) of Noxa… 

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