The cell cycle-regulatory CDC25A phosphatase inhibits apoptosis signal-regulating kinase 1.

@article{Zou2001TheCC,
  title={The cell cycle-regulatory CDC25A phosphatase inhibits apoptosis signal-regulating kinase 1.},
  author={Xianghong Zou and Tateki Tsutsui and Dipankar Ray and James F Blomquist and Hidenori Ichijo and David S. Ucker and Hiroaki Kiyokawa},
  journal={Molecular and cellular biology},
  year={2001},
  volume={21 14},
  pages={4818-28}
}
CDC25A phosphatase promotes cell cycle progression by activating G(1) cyclin-dependent kinases and has been postulated to be an oncogene because of its ability to cooperate with RAS to transform rodent fibroblasts. In this study, we have identified apoptosis signal-regulating kinase 1 (ASK1) as a CDC25A-interacting protein by yeast two-hybrid screening. ASK1 activates the p38 mitogen-activated protein kinase (MAPK) and c-Jun NH(2)-terminal protein kinase-stress-activated protein kinase (JNK… CONTINUE READING