The cell cycle regulator CDC25A is a target for JAK2V617F oncogene.

  title={The cell cycle regulator CDC25A is a target for JAK2V617F oncogene.},
  author={Emilie-Fleur Gautier and Muriel Picard and Camille Laurent and Caroline Marty and J L Villeval and C Saura Demur and François Delhommeau and Elizabeth O Hexner and St{\'e}phane Giraudier and Nicolas Bonnevialle and Bernard Ducommun and Christian R{\'e}cher and Guy Laurent and St{\'e}phane Manenti and V{\'e}ronique Mansat-De Mas},
  volume={119 5},
The JAK2(V617F) mutation is present in the majority of patients with polycythemia vera and one-half of those with essential thrombocythemia and primary myelofibrosis. JAK2(V617F) is a gain-of-function mutation resulting in constitutive JAK2 signaling involved in the pathogenesis of these diseases. JAK2(V617F) has been shown to promote S-phase entry. Here, we demonstrate that the CDC25A phosphatase, a key regulator of the G1/S cell-cycle transition, is constitutively overexpressed in JAK2(V617F… CONTINUE READING


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