The cell-cycle regulated proliferating cell nuclear antigen is required for SV40 DNA replication in vitro

@article{Prelich1987TheCR,
  title={The cell-cycle regulated proliferating cell nuclear antigen is required for SV40 DNA replication in vitro},
  author={G. Prelich and M. Kostura and D. Marshak and M. Mathews and B. Stillman},
  journal={Nature},
  year={1987},
  volume={326},
  pages={471-475}
}
Cell-free extracts prepared from human 293 cells, supplemented with purified SV40 large-T antigen, support replication of plasmids containing the SV40 origin of DNA replication. A cellular protein (Mr ∼36,000) that is required for efficient SV40 DNA synthesis in vitro has been purified from these extracts. This protein is recognized by human autoantibodies and is identified as the cell-cycle regulated protein known as proliferating cell nuclear antigen (PCNA) or cyclin. 
Cellular factors required for papillomavirus DNA replication.
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