The cell cycle kinases.

  title={The cell cycle kinases.},
  author={Jonathon Pines},
  journal={Seminars in cancer biology},
  volume={5 4},
This review summarizes our current knowledge of the regulation of the cell cycle by the cyclin-dependent kinase family (CDK). The CDKs are regulated both by binding their cyclin partners, and by phosphorylation of certain key residues. Cyclin synthesis and destruction are regulated during the cell cycle, and there are two broad classes of cyclins: the START or G1 cyclins, and the mitotic or G2 cyclins. In vivo the different cyclins and CDKs demonstrate a high degree of specificity in binding to… CONTINUE READING

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