The cell cycle control gene ZAC/PLAGL1 is imprinted--a strong candidate gene for transient neonatal diabetes.

@article{Kamiya2000TheCC,
  title={The cell cycle control gene ZAC/PLAGL1 is imprinted--a strong candidate gene for transient neonatal diabetes.},
  author={Megumi Kamiya and Hannah Judson and Yasushi Okazaki and Moriaki Kusakabe and M. Muramatsu and Shuji Takada and Nobuo Takagi and Takahiro Arima and Norio Wake and Kouhei Kamimura and Kazuhito Satomura and Ralph Hermann and David T. Bonthron and Yoshihide Hayashizaki},
  journal={Human molecular genetics},
  year={2000},
  volume={9 3},
  pages={453-60}
}
We describe a screen for new imprinted human genes, and the identification in this way of ZAC (zinc finger protein which regulates apoptosis and cell cycle arrest)/ PLAGL1 (pleomorphicadenoma of the salivary gland gene like 1) as a strong candidate gene for transient neonatal diabetes mellitus (TNDM). To screen for imprinted genes, we compared parthenogenetic DNA from the chimeric patient FD and androgenetic DNA from hydatidiform mole, using restriction landmark genome scanning for methylation… CONTINUE READING

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