The cell cycle control element of histone H4 gene transcription is maximally responsive to interferon regulatory factor pairs IRF-1/IRF-3 and IRF-1/IRF-7.

@article{Xie2001TheCC,
  title={The cell cycle control element of histone H4 gene transcription is maximally responsive to interferon regulatory factor pairs IRF-1/IRF-3 and IRF-1/IRF-7.},
  author={R Xie and Andre J van Wijnen and Caroline M J van der Meijden and Mai X. Luong and Janet L Stein and Gary S Stein},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 21},
  pages={18624-32}
}
Interferon regulatory factors (IRFs) are transcriptional mediators of interferon-responsive signaling pathways that are involved in antiviral defense, immune response, and cell growth regulation. To investigate the role of IRF proteins in the regulation of histone H4 gene transcription, we compared the transcriptional contributions of IRF-1, IRF-2, IRF-3, and IRF-7 using transient transfection assays with H4 promoter/luciferase (Luc) reporter genes. These IRF proteins up-regulate reporter gene… CONTINUE READING

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