The cell cycle arrest and the anti-invasive effects of nitrogen-containing bisphosphonates are not mediated by DBF4 in breast cancer cells.

@article{Mansouri2014TheCC,
  title={The cell cycle arrest and the anti-invasive effects of nitrogen-containing bisphosphonates are not mediated by DBF4 in breast cancer cells.},
  author={Mahdieh Mansouri and Seyed Abbas Mirzaei and Hermann Lage and Seyyedeh Soghra Mousavi and Fatemeh Elahian},
  journal={Biochimie},
  year={2014},
  volume={99},
  pages={71-6}
}
Recent work has shown that a DBF4 analog in yeast may be a target of nitrogen-containing bisphosphonates. DBF4 is an essential protein kinase required for DNA replication from primary eukaryotes to humans and appears to play a critical role in the S-phase checkpoint. It is also required for cell migration and cell surface adhesion. The effects of… CONTINUE READING