The cell cycle and regulation of cancer cell growth.

  title={The cell cycle and regulation of cancer cell growth.},
  author={Rachel Leake},
  journal={Annals of the New York Academy of Sciences},
  • Rachel Leake
  • Published 1996 in Annals of the New York Academy of Sciences
There are two points (brake-points) through which the cell must pass before it can enter cell division. Progress through each brake-point requires the presence of an active cyclin-dependent kinase (Cdk). There are specific cyclins to activate the Cdk's at different parts of the cell cycle. Activation of the cyclin-Cdk complex is tightly regulated by the phosphorylation state of the Cdk. Exogenous growth stimulators (hormones, growth factors, and cytokines) all work through an intracellular… CONTINUE READING

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