The cell biology of parathyroid hormone in osteoblasts.

  title={The cell biology of parathyroid hormone in osteoblasts.},
  author={Stavroula Kousteni and John P. Bilezikian},
  journal={Current osteoporosis reports},
  volume={6 2},
Continuous exposure to parathyroid hormone (PTH) is associated with catabolic effects, whereas intermittent exposure to low doses of PTH is associated with anabolic effects. By controlling osteoblast function, PTH increases bone formation on cancellous, endocortical, and periosteal bone surfaces. In general, PTH does not affect the replication of uncommitted osteoblast progenitors but suppresses proliferation of committed osteoprogenitors. Intermittent PTH promotes osteoblast differentiation… CONTINUE READING