The cell biology of disease Cell biology of spinocerebellar ataxia

@inproceedings{Orr2012TheCB,
  title={The cell biology of disease Cell biology of spinocerebellar ataxia},
  author={Harry T. Orr},
  year={2012}
}
Correspondence to Harry T. Orr: orrxx002@umn.edu Abbreviations used in this paper: ALS, amyotrophic lateral sclerosis; ATXN, ataxin; CHIP, C terminus of Hsc70-interacting protein; DUB, deubiquitinating enzyme; NLS, nuclear localization sequence; polyQ, polyglutamine; SCA, spinocerebellar ataxia. Individuals suffering from ataxia are at first clumsy and unable to walk steadily, and have slurred speech. Patients can eventually lose the ability to swallow and breathe in a coordinated fashion… CONTINUE READING

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