The cell biology of asthma

  title={The cell biology of asthma},
  author={David J. Erle and Dean Sheppard},
  booktitle={The Journal of cell biology},
The clinical manifestations of asthma are caused by obstruction of the conducting airways of the lung. Two airway cell types are critical for asthma pathogenesis: epithelial cells and smooth muscle cells. Airway epithelial cells, which are the first line of defense against inhaled pathogens and particles, initiate airway inflammation and produce mucus, an important contributor to airway obstruction. The other main cause of airway obstruction is contraction of airway smooth muscle. Complementary… CONTINUE READING