The cell and molecular biology of glaucoma: mechanisms in the conventional outflow pathway.

@article{Stamer2012TheCA,
  title={The cell and molecular biology of glaucoma: mechanisms in the conventional outflow pathway.},
  author={W. Stamer},
  journal={Investigative ophthalmology & visual science},
  year={2012},
  volume={53 5},
  pages={
          2470-2
        }
}
  • W. Stamer
  • Published 2012
  • Medicine
  • Investigative ophthalmology & visual science
Glaucoma, a blinding disease that affects millions in the United States, is treatable. Multiple clinical trials involving thousands of patients have repeatedly shown that lowering intraocular pressure (IOP) saves vision in those with glaucoma. In fact, if IOP in those with glaucoma is lowered sufficiently, vision loss dramatically slows—nearly stopping. IOP is a function of the balance of fluid (aqueous humor) entering and leaving the eye. Although there are very good medications that lower IOP… Expand
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References

SHOWING 1-10 OF 21 REFERENCES
Targeting outflow facility in glaucoma management.
  • 108
eNOS, a pressure-dependent regulator of intraocular pressure.
  • 126
Increased expression of the WNT antagonist sFRP-1 in glaucoma elevates intraocular pressure.
  • 131
  • PDF
The changing paradigm of outflow resistance generation: towards synergistic models of the JCT and inner wall endothelium.
  • 175
  • PDF
S1P₂ receptor regulation of sphingosine-1-phosphate effects on conventional outflow physiology.
  • G. Sumida, W. Stamer
  • Chemistry, Medicine
  • American journal of physiology. Cell physiology
  • 2011
  • 30
  • PDF
Effects of TGF-beta2 in perfused human eyes.
  • 222
  • PDF
Glaucoma-associated myocilin: a better understanding but much more to learn.
  • 89
NO-induced regulation of human trabecular meshwork cell volume and aqueous humor outflow facility involve the BKCa ion channel.
  • 87
  • PDF
The role of the prostaglandin EP4 receptor in the regulation of human outflow facility.
  • 27
  • PDF
Cationic ferritin changes outflow facility in human eyes whereas anionic ferritin does not.
  • 69
...
1
2
3
...