The cdk5 kinase regulates the STAT3 transcription factor to prevent DNA damage upon topoisomerase I inhibition.

@article{Courapied2010TheCK,
  title={The cdk5 kinase regulates the STAT3 transcription factor to prevent DNA damage upon topoisomerase I inhibition.},
  author={Sandy Courapied and H{\'e}l{\`e}ne Sellier and Sophie de Carn{\'e} Tr{\'e}cesson and Arnaud Vigneron and A Bernard and Erick Gamelin and Benjamin Barr{\'e} and Olivier Coqueret},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 35},
  pages={26765-78}
}
The STAT3 transcription factors are cytoplasmic proteins that induce gene activation in response to growth factor stimulation. Following tyrosine phosphorylation, STAT3 proteins dimerize, translocate to the nucleus, and activate specific target genes involved in cell-cycle progression. Despite its importance in cancer cells, the molecular mechanisms by which this protein is regulated in response to DNA damage remain to be characterized. In this study, we show that STAT3 is activated in response… CONTINUE READING