The causes and consequences of HIV evolution

@article{Rambaut2004TheCA,
  title={The causes and consequences of HIV evolution},
  author={Andrew Rambaut and David Posada and Keith A. Crandall and Edward C. Holmes},
  journal={Nature Reviews Genetics},
  year={2004},
  volume={5},
  pages={52-61}
}
Understanding the evolution of the human immunodeficiency virus (HIV) is crucial for reconstructing its origin, deciphering its interaction with the immune system and developing effective control strategies. Although it is clear that HIV-1 and HIV-2 originated in African primates, dating their transmission to humans is problematic, especially because of frequent recombination. Our ability to predict the spread of drug-resistance and immune-escape mutations depends on understanding how HIV… 
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