The cause of the Chinese sofa/chair dermatitis epidemic is likely to be contact allergy to dimethylfumarate, a novel potent contact sensitizer

@article{Rantanen2008TheCO,
  title={The cause of the Chinese sofa/chair dermatitis epidemic is likely to be contact allergy to dimethylfumarate, a novel potent contact sensitizer},
  author={Tapio Rantanen},
  journal={British Journal of Dermatology},
  year={2008},
  volume={159}
}
  • T. Rantanen
  • Published 2008
  • Medicine
  • British Journal of Dermatology
Background  A small epidemic of severe contact dermatitis cases related to newly acquired sofas and chairs has surpassed the news threshold in Finland and the U.K. 
Dimethyl fumarate contact dermatitis of the foot: an increasingly widespread disease
Background  Dimethyl fumarate (DMF) has been recognized as an extremely potent irritant and sensitizer found in sachets inside furniture. The first skin manifestations were correlated to contact withExpand
Contact dermatitis caused by dimethylfumarate in Argentina
TLDR
It is identified that new pairs of shoes caused intense pruritus, pain, and eruption, followed by edema, blisters, and a severe negative impact on the epidermal barrier of the feet. Expand
Shoe contact dermatitis from dimethyl fumarate: clinical manifestations, patch test results, chemical analysis, and source of exposure
TLDR
The methyl ester form of fumaric acid named dimethyl fumarate (DMF) is an effective mould‐growth inhibitor and has been identified as responsible for furniture contact dermatitis in Europe. Expand
Leucoderma after Chinese sofa dermatitis
TLDR
A case of allergic contact dermatitis caused by dimethylfumarate present in a leather sofa was described, which was followed by persistent depigmentation after the resolution of eczematous lesions. Expand
Dimethylfumarate: potency prediction and clinical experience
Background. Dimethylfumarate (DMF) was the cause of a major outbreak of allergic contact dermatitis as a consequence of its use as an antifungal agent in leather products, particularly in furniture,Expand
An epidemic of furniture‐related dermatitis: searching for a cause
Background  Sitting in new chairs or sofas has elicited dermatitis in numerous patients in Finland and in the U.K. since autumn 2006. The cause of the dermatitis seemed to be an allergen in theExpand
Sensitization to dimethyl fumarate with multiple concurrent patch test reactions
Background: Chairs and sofas imported from China to Europe were shown to contain dimethyl fumarate (DMF), a sensitizing, volatile chemical. Many of the sensitized patients also had positive patchExpand
Correlation between lesion site and concentration of dimethyl fumarate in different parts of shoes in patients with contact dermatitis caused by dimethyl fumarate in footwear
TLDR
An outbreak of shoe contact dermatitis in Europe has involved the dorsa of the toes and the dorsA of the feet, sometimes in association with other areas. Expand
Footwear contact dermatitis from dimethyl fumarate
TLDR
The aim of this study was to evaluate patients in Slovakia with footwear ACD associated with DMF with regard to clinical manifestations, patch test results, and results of chemical analysis of their footwear. Expand
[Contact dermatitis due to dimethyl fumarate].
TLDR
The clinical manifestations, results of patch tests, possible cross-reactions, and sources of exposure to dimethyl fumarate responsible for these skin reactions are reviewed. Expand
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References

SHOWING 1-10 OF 13 REFERENCES
[Two cases of side effects of a fumaric acid ester--local therapy].
TLDR
One patient suffering from atopic dermatitis reacted with contact dermatitis; the other, suffering from psoriasis, developed a generalized, partly pustulous exanthema as well as signs of systemic involvement, such as tachycardia and dyspnea. Expand
Manual of Contact Dermatitis
Fregert'sManual of Contact Dermatitisis packed with useful information and is highly recommended as a primer for those learning dermatology and as a brief refresher text for the practicing clinician.Expand
The risk of sensibilization and contact urticaria upon topical application of fumaric acid derivatives.
TLDR
The results of the cytotoxicity test demonstrated that dimethylfumarate (DMF) was the most toxic derivative and both MEF and DMF are moderate contact sensitizers. Expand
Treatment of psoriasis with fumaric acid esters (Fumaderm®)
TLDR
The following guidelines deal with practical aspects of psoriasis treatment with fumaric acid esters, based on current knowledge of scientific research and therapeutic experiences. Expand
Stereochemical Considerations on Concomitant Allergic Contact Dermatitis to Ester of the cis-trans Isomeric Compounds Maleic Acid and Fumaric Acid
TLDR
Stereochemical considerations point to a general mechanism where cis-trans isomeric α,β-unsaturated carbonyl compounds are converted into the same complete antigen. Expand
Differential suppression of dendritic cell cytokine production by anti‐inflammatory drugs
TLDR
The objective of this study was to establish an experimental procedure and show results that unequivocally can be attributed to maturation and polarization of dendritic cells in response to anti‐inflammatory drugs. Expand
The relationships between exposure dose and response in induction and elicitation of contact hypersensitivity in humans
TLDR
It is clear that the dose–response relationships for induction of sensitivity by repeated low‐dose exposures must be carefully defined in future studies. Expand
Drug evaluation: BG-12, an immunomodulatory dimethylfumarate.
TLDR
No further development has been reported on BG-12 for psoriasis in the US and it was not listed as a pursued indication on Biogen Idec's April 2007 pipeline. Expand
Dimethylfumarate reduces leukocyte rolling in vivo through modulation of adhesion molecule expression.
TLDR
Early evidence is provided that DMF affects adhesion molecule expression on human leukocytes and their rolling behavior in vivo, indicating thatDMF directly affects the initial step of leukocyte extravasation. Expand
Dimethylfumarate specifically inhibits the mitogen and stress-activated kinases 1 and 2 (MSK1/2): possible role for its anti-psoriatic effect.
TLDR
The results suggest that DMF specifically inhibits MSK1 and 2 activations and subsequently inhibits NF-kappaB-induced gene-transcriptions, which are believed to be important in the pathogenesis of psoriasis, and explain the anti-psoriatic effect of FAEs. Expand
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