The causal role of smoking in anxiety and depression: a Mendelian randomization analysis of the HUNT study.

@article{Bjrngaard2013TheCR,
  title={The causal role of smoking in anxiety and depression: a Mendelian randomization analysis of the HUNT study.},
  author={Johan H{\aa}kon Bj\orngaard and D Gunnell and Maiken Bratt Elvestad and George Davey Smith and Frank Skorpen and Hans Einar Krokan and Lars J Vatten and P{\aa}l Rikard Romundstad},
  journal={Psychological medicine},
  year={2013},
  volume={43 4},
  pages={711-9}
}
BACKGROUND Cigarette smoking is strongly associated with mental illness but the causal direction of the association is uncertain. We investigated the causal relationship between smoking and symptoms of anxiety and depression in the Norwegian HUNT study using the rs1051730 single nucleotide polymorphism (SNP) variant located in the nicotine acetylcholine receptor gene cluster on chromosome 15 as an instrumental variable for smoking phenotypes. Among smokers, this SNP is robustly associated with… CONTINUE READING
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The Association of Cigarette Smoking With Depression and Anxiety: A Systematic Review

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