The causal role of megakaryocyte–platelet hyperactivity in acute coronary syndromes

  title={The causal role of megakaryocyte–platelet hyperactivity in acute coronary syndromes},
  author={John Martin and Steen Dalby Kristensen and Anthony Mathur and Erik Lerkevang Grove and Fizzah Aziz Choudry},
  journal={Nature Reviews Cardiology},
Platelets are causally involved in coronary artery obstruction in acute coronary syndromes (ACS). This cell type is unique to mammals and its production, which is unlike that of any other mammalian cell, involves polyploid nuclear change in the mother cell (megakaryocyte) and the production of anucleate cells with a log Gaussian distribution of volume. Platelets vary more in cellular volume than any other circulating blood element in mammals. Larger platelets are denser, contain more secretory… CONTINUE READING


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