The cationic peptide LL-37 binds Mac-1 (CD11b/CD18) with a low dissociation rate and promotes phagocytosis.

Abstract

As a broad-spectrum anti-microbial peptide, LL-37 plays an important role in the innate immune system. A series of previous reports implicates LL-37 as an activator of various cell surface receptor-mediated functions, including chemotaxis in integrin CD11b/CD18 (Mac-1)-expressing cells. However, evidence is scarce concerning the direct binding of LL-37 to… (More)
DOI: 10.1016/j.bbapap.2016.02.013

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Cite this paper

@article{Zhang2016TheCP, title={The cationic peptide LL-37 binds Mac-1 (CD11b/CD18) with a low dissociation rate and promotes phagocytosis.}, author={Xianwei Zhang and Goran Bajic and Gregers Rom Andersen and Stig Hill Christiansen and Thomas Vorup-Jensen}, journal={Biochimica et biophysica acta}, year={2016}, volume={1864 5}, pages={471-8} }