The cationic cell-penetrating peptide CPP(TAT) derived from the HIV-1 protein TAT is rapidly transported into living fibroblasts: optical, biophysical, and metabolic evidence.

@article{Ziegler2005TheCC,
  title={The cationic cell-penetrating peptide CPP(TAT) derived from the HIV-1 protein TAT is rapidly transported into living fibroblasts: optical, biophysical, and metabolic evidence.},
  author={Andr{\'e} Ziegler and Pierluigi Nervi and Markus D{\"u}rrenberger and Joachim Dr. Seelig},
  journal={Biochemistry},
  year={2005},
  volume={44 1},
  pages={
          138-48
        }
}
Cell-penetrating peptides (CPPs) are cationic peptides which, when linked to genes, proteins, or nanoparticles, facilitate the transport of these entities across the cell membrane. Despite their potential use for gene transfer and drug delivery, the mode of action of CPPs is still mysterious. It has even been argued that the observed transport across the cell membrane is an artifact caused by chemical fixation of the cells, a common preparation method for microscopic observation. Here we have… CONTINUE READING
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