The cation-dependent G-proteins: in a class of their own.

  title={The cation-dependent G-proteins: in a class of their own.},
  author={Miriam-Rose Ash and Megan Maher and J Mitchell Guss and Mika Jormakka},
  journal={FEBS letters},
  volume={586 16},
G-proteins are some of the most important and abundant enzymes, yet their intrinsic nucleotide hydrolysis reaction is notoriously slow and must be accelerated in vivo. Recent experiments on dynamin and GTPases involved in ribosome assembly have demonstrated that their hydrolysis activities are stimulated by potassium ions. This article presents the hypothesis that cation-mediated activation of G-proteins is more common than currently realised, and that such GTPases represent a structurally and… CONTINUE READING