The cathepsin B death pathway contributes to TNF plus IFN-gamma-mediated human endothelial injury.

@article{Li2005TheCB,
  title={The cathepsin B death pathway contributes to TNF plus IFN-gamma-mediated human endothelial injury.},
  author={Jie Hui Li and Jordan S Pober},
  journal={Journal of immunology},
  year={2005},
  volume={175 3},
  pages={1858-66}
}
Vascular endothelial cells are primary targets of cytokine-induced cell death leading to tissue injury. We previously reported that TNF in combination with LY294002, a PI3K inhibitor, activates caspase-independent cell death initiated by cathepsin B (Cat B) in HUVEC. We report that TNF in the presence of IFN-gamma activates Cat B as well as a caspase death pathway in both HUVEC and human dermal microvascular endothelial cells, but only activates caspase-mediated death in HeLa cells and human… CONTINUE READING
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