The catecholic metal sequestering agent 1,2-dihydroxybenzene-3,5-disulfonate confers protection against oxidative cell damage.

@article{Krishna1992TheCM,
  title={The catecholic metal sequestering agent 1,2-dihydroxybenzene-3,5-disulfonate confers protection against oxidative cell damage.},
  author={Chilakapati Murali Krishna and J. E. Liebmann and David H Kaufman and William G Degraff and Stephen M. Hahn and Thomas J. McMurry and James B. Mitchell and Angelo Russo},
  journal={Archives of biochemistry and biophysics},
  year={1992},
  volume={294 1},
  pages={98-106}
}
Tiron (1,2-dihydroxybenzene-3,5-disulfonate), a nontoxic chelator of a variety of metals, is used to alleviate acute metal overload in animals. It is also oxidized to the EPR-detectable semiquinone radical by various biologically relevant oxidants, such as .OH, O2-., alkyl, and alkoxyl radicals. Since Tiron reacts with potentially toxic intracellular species and is also a metal chelator, we evaluated its protective effects in V79 cells subjected to various types of oxidative damage and… CONTINUE READING