The catalytic triad of serine peptidases

  title={The catalytic triad of serine peptidases},
  author={László Polgár},
  journal={Cellular and Molecular Life Sciences CMLS},
  • L. Polgár
  • Published 7 July 2005
  • Biology, Chemistry
  • Cellular and Molecular Life Sciences CMLS
Abstract.The catalytic action of serine peptidases depends on the interplay of a nucleophile, a general base and an acid. In the classic trypsin and subtilisin families this catalytic triad is composed of serine, histidine and aspartic acid residues and exhibits similar spatial arrangements, but the order of the residues in the amino acid sequence is different. By now several new families have been discovered, in which the nucleophile-base-acid pattern is generally conserved, but the individual… 

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