The catalytic subunit of cAMP-dependent protein kinase induces expression of genes containing cAMP-responsive enhancer elements

@article{Riabowol1988TheCS,
  title={The catalytic subunit of cAMP-dependent protein kinase induces expression of genes containing cAMP-responsive enhancer elements},
  author={Karl T. Riabowol and J. Stephen Fink and Michael Z. Oilman and Donal A. Walsh and Richard Goodman and James R. Feramisco},
  journal={Nature},
  year={1988},
  volume={336},
  pages={83-86}
}
Transcriptional regulation of eukaryotic genes by cyclic AMP requires a cAMP-dependent protein kinase (A kinase)1. Two hypotheses have been proposed to explain how the holoenzyme of the A kinase induces transcription. The regulatory subunits of the A kinase, which bind cAMP2 and DNA3, and have amino-acid homology with the Escherichia coli catabolite activator protein4 could directly stimulate gene expression5,6. Alternatively, phos-phorylation by the catalytic subunits could induce… CONTINUE READING

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