The catalytic domain of a bacterial lytic transglycosylase defines a novel class of lysozymes.

@article{Thunnissen1995TheCD,
  title={The catalytic domain of a bacterial lytic transglycosylase defines a novel class of lysozymes.},
  author={Andy Mark W H Thunnissen and Neil W. Isaacs and Bauke W Dijkstra},
  journal={Proteins},
  year={1995},
  volume={22 3},
  pages={245-58}
}
The 70-kDa soluble lytic transglycosylase (SLT70) from Escherichia coli is a bacterial exo-muramidase that cleaves the cell wall peptidoglycan, producing 1,6-anhydro-muropeptides. The X-ray structure of SLT70 showed that one of its domains is structurally related to lysozyme, although there is no obvious similarity in amino acid sequence. To relate discrete structural features to differences in reaction mechanism and substrate/product specificity, we compared the three-dimensional structure of… CONTINUE READING