The catalytic and lectin domains of UDP-GalNAc:polypeptide alpha-N-Acetylgalactosaminyltransferase function in concert to direct glycosylation site selection.

Abstract

UDP-GalNAc:polypeptide alpha-N-Acetylgalactosaminyltransferases (ppGalNAcTs), a family (EC 2.4.1.41) of enzymes that initiate mucin-type O-glycosylation, are structurally composed of a catalytic domain and a lectin domain. Previous studies have suggested that the lectin domain modulates the glycosylation of glycopeptide substrates and may underlie the… (More)
DOI: 10.1074/jbc.M803387200

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@article{Raman2008TheCA, title={The catalytic and lectin domains of UDP-GalNAc:polypeptide alpha-N-Acetylgalactosaminyltransferase function in concert to direct glycosylation site selection.}, author={Jayalakshmi Raman and Timothy A Fritz and Thomas A. Gerken and Oliver Jamison and David H Live and Mian Liu and Lawrence A. Tabak}, journal={The Journal of biological chemistry}, year={2008}, volume={283 34}, pages={22942-51} }