The catalytic activity of dsRNA-dependent protein kinase, PKR, is required for NF-κB activation

@article{Gil2001TheCA,
  title={The catalytic activity of dsRNA-dependent protein kinase, PKR, is required for NF-κB activation},
  author={Jes{\'u}s Gil and Joaqu{\'i}n Rull{\'a}s and Mar{\'i}a Angel Garc{\'i}a and Jos{\'e} Javier Rivera Alcam{\'i} and Mariano Est{\'e}ban},
  journal={Oncogene},
  year={2001},
  volume={20},
  pages={385-394}
}
The double stranded RNA-dependent protein kinase (PKR), in addition to its role as a translational controlling factor, is a key transcriptional regulator exerting antiviral and antitumoral activities. We have previously shown that induction of NF-κB by PKR is involved in apoptosis commitment and this process is mediated through activation of the IKK complex. To gain insights into the mechanism of activation of NF-κB by PKR, we have analysed the domains of PKR involved in IKK activation and… CONTINUE READING

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