The catalytic activity for ginkgolic acid biodegradation, homology modeling and molecular dynamic simulation of salicylic acid decarboxylase

@article{Hu2018TheCA,
  title={The catalytic activity for ginkgolic acid biodegradation, homology modeling and molecular dynamic simulation of salicylic acid decarboxylase},
  author={Yanying Hu and Qingyuan Hua and Guojuan Sun and Kunpeng Shi and Huitu Zhang and Kai Zhao and S. Jia and Yujie Dai and Q. Wu},
  journal={Computational biology and chemistry},
  year={2018},
  volume={75},
  pages={
          82-90
        }
}
  • Yanying Hu, Qingyuan Hua, +6 authors Q. Wu
  • Published 2018
  • Medicine, Computer Science, Biology
  • Computational biology and chemistry
  • The toxic ginkgolic acids are the main safety concern for the application of Ginkgo biloba. In this study, the degradation ability of salicylic acid decarboxylase (SDC) for ginkgolic acids was examined using ginkgolic acid C15:1 as a substrate. The results indicated that the content of ginkgolic acid C15:1 in Ginkgo biloba seeds was significantly decreased after 5 h treatment with SDC at 40 °Cand pH 5.5. In order to explore the structure of SDC and the interaction between SDC and substrates… CONTINUE READING

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