The catabolic pathway mediated by Toll-like receptors in human osteoarthritic chondrocytes.

@article{Kim2006TheCP,
  title={The catabolic pathway mediated by Toll-like receptors in human osteoarthritic chondrocytes.},
  author={Hyun Ah Kim and Mi-La Cho and Hye Young Choi and Chang Sik Yoon and Joo Yeon Jhun and Hey Jwa Oh and Hang-Rae Kim},
  journal={Arthritis and rheumatism},
  year={2006},
  volume={54 7},
  pages={2152-63}
}
OBJECTIVE To examine the catabolic pathways mediated by Toll-like receptor (TLR) ligands in human osteoarthritic (OA) chondrocytes. METHODS The presence of TLRs in OA and non-OA articular cartilage was analyzed by immunohistochemistry. The regulation of TLR messenger RNA (mRNA) by interleukin-1 (IL-1) and tumor necrosis factor alpha (TNFalpha) was analyzed by reverse transcription-polymerase chain reaction. For stimulation of TLR-2 and TLR-4, chondrocytes were treated with Staphylococcus… CONTINUE READING

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