The caspase-independent algorithm of programmed cell death in Leishmania induced by baicalein: the role of LdEndoG, LdFEN-1 and LdTatD as a DNA ‘degradesome’

Abstract

In the post-genomic perspective, the quest of programmed cell death (PCD) mechanisms in kinetoplastid parasites lies in the identification and characterization of cell death executer proteins. Here, we show that baicalein (BLN), a potent topoisomerase IB inhibitor, generates an oxidative stress in the parasites leading to altered physiological and… (More)
DOI: 10.1038/cdd.2008.85

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@article{Bosedasgupta2008TheCA, title={The caspase-independent algorithm of programmed cell death in Leishmania induced by baicalein: the role of LdEndoG, LdFEN-1 and LdTatD as a DNA ‘degradesome’}, author={Somdeb Bosedasgupta and Benu Brata Das and Sanjeev Sengupta and Ashish Ganguly and Alec Roy and Sunanda Dey and Gyanendra Nath Tripathi and Banamali Dinda and Hemanta Kumar Majumder}, journal={Cell Death and Differentiation}, year={2008}, volume={15}, pages={1629-1640} }