The case test-negative design for studies of the effectiveness of influenza vaccine in inpatient settings

Abstract

Background The test-negative design (TND) to evaluate influenza vaccine effectiveness is based on patients seeking care for acute respiratory infection, with those who test positive for influenza as cases and the test-negatives serving as controls. This design has not been validated for the inpatient setting where selection bias might be different from an… (More)
DOI: 10.1093/ije/dyw022

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