The case of oncolytic viruses versus the immune system: waiting on the judgment of Solomon.

@article{Prestwich2009TheCO,
  title={The case of oncolytic viruses versus the immune system: waiting on the judgment of Solomon.},
  author={Robin J D Prestwich and Fiona Errington and Rosa Mar{\'i}a D{\'i}az and Hardev S. Pandha and Kevin J. Harrington and Alan A Melcher and Richard G. Vile},
  journal={Human gene therapy},
  year={2009},
  volume={20 10},
  pages={1119-32}
}
The three-way interaction between oncolytic viruses, the tumor microenvironment, and the immune system is critical to the outcome of antitumor therapy. Classically, the immune system is thought to limit the efficacy of therapy, leading to viral clearance. However, preclinical and clinical data suggest that in some cases virotherapy may in fact act as cancer immunotherapy. In this review we discuss the ability of oncolytic viruses to alter the immunogenic milieu of the tumor microenvironment… CONTINUE READING

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The Immune System in Oncolytic Immunovirotherapy: Gospel, Schism and Heresy.

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