The case for rejecting the amyloid cascade hypothesis


Alzheimer's disease (AD) is a biologically complex neurodegenerative dementia. Nearly 20 years ago, with the combination of observations from biochemistry, neuropathology and genetics, a compelling hypothesis known as the amyloid cascade hypothesis was formulated. The core of this hypothesis is that it is pathological accumulations of amyloid-β, a peptide… (More)
DOI: 10.1038/nn.4017


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@article{Herrup2015TheCF, title={The case for rejecting the amyloid cascade hypothesis}, author={Karl Herrup}, journal={Nature Neuroscience}, year={2015}, volume={18}, pages={794-799} }