The case for medical marijuana in epilepsy

@article{Maa2014TheCF,
  title={The case for medical marijuana in epilepsy},
  author={Edward H. Maa and Paige Figi},
  journal={Epilepsia},
  year={2014},
  volume={55}
}
Charlotte, a little girl with SCN1A‐confirmed Dravet syndrome, was recently featured in a special that aired on CNN. Through exhaustive personal research and assistance from a Colorado‐based medical marijuana group (Realm of Caring), Charlotte's mother started adjunctive therapy with a high concentration cannabidiol/Δ9‐tetrahydrocannabinol (CBD:THC) strain of cannabis, now known as Charlotte's Web. This extract, slowly titrated over weeks and given in conjunction with her existing antiepileptic… 

Cannabis in epilepsy: From clinical practice to basic research focusing on the possible role of cannabidivarin

The patient affected by symptomatic partial epilepsy who used cannabis as self‐medication after the failure of countless pharmacological/surgical treatments supports the hypothesis that cannabis could actually represent an effective, well‐tolerated antiepileptic drug and suggests that CBDV may greatly contribute to cannabis anticonvulsant effect through its possible GABAergic action.

Cannabinoids for paediatric epilepsy: Weeding out the issues

There has been increasing media interest and public discussion regarding a potential utility for cannabis in paediatric epilepsy, and there is strong theoretical and experimental evidence from animal studies to suggest that cannabinoids may be effective anticonvulsants.

The Knowledge Gaps for Medical Marijuana in Pediatric Conditions.

Patients, families, and physicians are confronted with a scarcity of evidence on the safety, efficacy, and tolerability of cannabinoids in the face of abundantEvidence on the long-term harms of marijuana use.

Cannabinoids in treatment-resistant epilepsy: A review

Cannabidiol Treatment for Refractory Epilepsies in Pediatrics

It is necessary to investigate CBD safety, pharmacokinetics and interaction with other AEDs alongside performing double-blinded placebo-controlled trials to obtain conclusive data on its efficacy and safety in the most frequent epilepsies in children, not just in the epileptic encephalopathy.

Marijuana Compounds: A Non-Conventional Therapeutic Approach to Epilepsy in Children

Principal concerns regarding the use of medical marijuana in children include lack of standardization and regulation, imprecise dosing, possible adverse side effects and medication interactions.

Cannabinoids in the Treatment of Epilepsy: Hard Evidence at Last?

  • E. Perucca
  • Medicine, Psychology
    Journal of epilepsy research
  • 2017
There is now class 1 evidence that adjunctive use of CBD improves seizure control in patients with specific epilepsy syndromes, for the first time, according to currently available information.

Cannabidiol in the Treatment of Epilepsy

The aim of this article is to thoroughly review available research data and practical recommendations to provide the treating physician with the necessary information for counseling patients with epilepsy.

Cannabis, More Than the Euphoria: Its Therapeutic Use in Drug-Resistant Epilepsy

It can safely be concluded that there is a significant benefit in DRE patients using CBD as adjunctive therapy, however, further controlled and adequately powered studies are needed to assess the pharmacokinetics and impact of the long-term use of cannabis.
...

References

SHOWING 1-10 OF 18 REFERENCES

Chronic administration of cannabidiol to healthy volunteers and epileptic patients.

Four of the 8 CBD subjects remained almost free of convulsive crises throughout the experiment and 3 other patients demonstrated partial improvement in their clinical condition, while CBD was ineffective in 1 patient.

Antiepileptic and Prophylactic Effects of Tetrahydrocannabinols in Amygdaloid Kindled Cats *

It is suggested that chronic administration of δ9‐THC during kindling might block the process of seizure development, which was supported by the observation that three of four cats failed to kindle when treated with the drug.

Taming THC: potential cannabis synergy and phytocannabinoid‐terpenoid entourage effects

Particular focus will be placed on phytocannabinoid‐terpenoid interactions that could produce synergy with respect to treatment of pain, inflammation, depression, anxiety, addiction, epilepsy, cancer, fungal and bacterial infections (including methicillin‐resistant Staphylococcus aureus).

Effects of Tetrahydrocannabinols on Kindled Amygdaloid Seizures and Photogenic Seizures in Senegalese Baboons, Papio papio

Intraperitoneal injections of delta 8‐tetrahy‐drocannabinol (THC) and delta 9‐THC failed to affect myoclonic response to photic stimulation in Senegalese baboons (Papio papio). However. both isomers

Agonistic Properties of Cannabidiol at 5-HT1a Receptors

These studies demonstrate that CBD is a modest affinity agonist at the human 5-HT1a receptor, and indicate that cannabidiol may have interesting and useful potential beyond the realm of cannabinoid receptors.

Anticonvulsant nature of marihuana smoking.

Marihuana smoking, in conjunction with therapeutic doses of phenobarbital and diphenylhydantoin, was apparently necessary for controlling seizures in one 24-year-old epileptic patient.

The orphan receptor GPR55 is a novel cannabinoid receptor

The endocannabinoid system functions through two well characterized receptor systems, the CB1 and CB2 receptors. Work by a number of groups in recent years has provided evidence that the system is