The case for DUF1220 domain dosage as a primary contributor to anthropoid brain expansion

Abstract

Here we present the hypothesis that increasing copy number (dosage) of sequences encoding DUF1220 protein domains is a major contributor to the evolutionary increase in brain size, neuron number, and cognitive capacity that is associated with the primate order. We further propose that this relationship is restricted to the anthropoid sub-order of primates… (More)
DOI: 10.3389/fnhum.2014.00427

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