The carriage of pro-inflammatory cytokine gene polymorphisms in recurrent pregnancy loss.

@article{Reid2001TheCO,
  title={The carriage of pro-inflammatory cytokine gene polymorphisms in recurrent pregnancy loss.},
  author={Janet G Reid and Nigel A. B. Simpson and Richard G. Walker and Olga Economidou and Jayne Shillito and Hock Chye Gooi and Sean R G Duffy and James J. Walker},
  journal={American journal of reproductive immunology},
  year={2001},
  volume={45 1},
  pages={35-40}
}
PROBLEM Recurrent pregnancy loss (RPL) affects 2-4% of couples, and remains largely unexplained. Recent studies have examined the role of cytokines in the maintenance of normal pregnancy, which is linked with an increased expression of Th2 cytokines. Overexpression of Th1 cytokines is associated with RPL. Knowing that functional polymorphisms exist for certain cytokines, it has therefore been suggested that women with RPL may have a genetic predisposition to overexpress Th1 cytokines. METHOD… CONTINUE READING

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